Charles Griffin (1825–1867) was a U.S. Army officer and Union general.
Charles or Charlie Griffin may also refer to: Charles A. Griffin (born 1884), American politician Charles Griffin (baseball) (), American baseball player Charles Griffin (Hudson's Bay Company), person involved in the Pig War Charles D. Griffin (1906–1996), U.S. Navy admiral Charles H. Griffin (1926–1989), U.S. Representative from Mississippi Charlie Griffin (born 1979), English footballer