SMB may refer to:
Business Small and medium businesses, also known as small and medium enterprises
Arts and entertainment Sveriges Medeltida Ballader, a compilation of Swedish medieval ballads Michigan State University Spartan Marching Band Super Mario Bros., a 1985 NES video game Super Mario Bros. (disambiguation), other articles related to the NES game Super Monkey Ball, a video game series Super Monkey Ball (video game), the first game in the series Super Meat Boy, a 2010 platform video game Super Mega Baseball, a sports video game series
Music "SMB" (song), by Odetari Hongjoong, 2025 "SMB", a song by Tech N9ne from Something Else, 2013
Science Society for Mathematical Biology Surface mass balance of a glacier or ice sheet
Technology Electronics and computing SMB connector, SubMiniature B connector System Management Bus, for computer communication Server Message Block (SMB or SMB/CIFS), a network protocol
Other technologies Simulated moving bed for chromatographic separation Surface marker buoy, to indicate a diver's position Survey motor boat, for hydrographic survey
Other uses San Miguel Beermen (disambiguation), the name of several Philippine basketball teams Sean Murphy-Bunting, an American footballer Sekolah Menengah Berakas (Berakas Secondary School), Brunei Seven Mile Beach, Grand Cayman Shimbashi Station (Tokyo), JR East station code Staatliche Museen zu Berlin, a group of museums in Berlin