Chief Buffalo may refer to a number of people:
Ojibwe
Chief Buffalo or Kechewaishke (1759–1855), Ojibwa chief of the La Pointe Band of Lake Superior Chippewa Buffalo, an Ojibwa chief of the St. Croix Band Beshekee (Buffalo), an Ojibwa chief of the Leech Lake Band
Sioux
Buffalo, a Dakota chief about St. Croix River Black Buffalo (chief) (1767–1823), Sioux leader
Other
White Buffalo (Cheyenne leader) (1862–1929), chief of the Northern Cheyenne Buffalo Hump, Comanche leader Chief Buffalo Child Long Lance (1890–1932), journalist, soldier and Native American impostor