Van Hoogstraten is a Dutch toponymic surname, meaning "from Hoogstraten" and may refer to:
Jacob van Hoogstraten (c. 1460–1527), Flemish Dominican theologian and controversialist Dirk van Hoogstraten (1596–1640), Dutch painter Samuel Dirksz van Hoogstraten (1627–1678), Dutch painter, poet, and author on art theory Jan van Hoogstraten (1628–1654), Dutch painter For other descendants of Dirk van Hoogstraten, see Willem van Hoogstraten (1884–1965), Dutch violinist and conductor Jacob Emil van Hoogstraten (1898–1991), Dutch senior public servant in colonial Indonesia Nicholas van Hoogstraten (born 1945), controversial British businessman