Nucleoporin p58/p45 is a protein that in humans is encoded by the NUP58 gene (previously NUPL1). The rat version of this gene produces distinct p45 and p58 isoforms (hence the name), but no analog of p45 has been found in humans yet.
This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC).
All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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