Latsis (; ) can be either a Greek surname or a Russified form of the Latvian language surname Lācis. Individuals with the surname include:
Spiros Latsis (born 1946), Greek banking and oil tycoon Yiannis Latsis (1910–2003), Greek shipping and oil tycoon Martin Latsis (1888–1938), Latvian-born Soviet politician, revolutionary and state security high officer Otto Latsis (1934–2005), Soviet and Russian journalist
See also Latsis Foundation