Jefferson Historic District may refer to several places in the United States:
Alphabetical by state
Jefferson Historic District (Jefferson, Alabama), listed on the National Register of Historic Places (NRHP) Jefferson Historic District (Jefferson, Georgia), NRHP-listed in Jackson County, Georgia Jefferson Historic District (Lafayette, Indiana), NRHP-listed Jefferson Historic District (Jefferson, New York), NRHP-listed in Schoharie County, New York Jefferson Historic District (Jefferson, Texas), NRHP-listed
See also Jefferson Avenue Historic District (disambiguation)