Simien or Semien may mean:
People Wayne Simien, an American professional basketball player Terrance Simien, a U.S. zydeco musician, accordionist and songwriter Tracy Simien, a former NFL football player
Places Kingdom of Simien, a Jewish kingdom said to have been located in the north-western part of Ethiopia Simien Mountains, Ethiopia Semien Mountains National Park
See also Simian, "pertaining to apes" Simian (disambiguation) Simion, a Romanian name