Cunliffe-Owen is a surname, and may refer to:
Sir Philip Cunliffe-Owen (1828–1894), English exhibition organizer and museum director Sir Hugo Cunliffe-Owen (1870–1947), English tobacco industrialist Frederick Cunliffe-Owen (1855–1926), British-born American journalist Cunliffe-Owen baronets, a title in the Baronetage of the United Kingdom created in 1920 for Hugo Cunliffe-Owen
See also Cunliffe-Owen Aircraft, a British aircraft manufacturer of the World War II era founded by Hugo Cunliffe-Owen