A muleskinner or mule skinner is a muleteer or mule-driver.

It is also a antiquated military slang term for a cavalryman.

Muleskinner may also refer to:

Muleskinners, a nickname for members of the 10th Sustainment Brigade Mule Skinner, the mascot of St. John's Military School, Kansas, U.S. Muleskinner, an alternate title for the album Jack Takes the Floor by Ramblin' Jack Elliott Muleskinner (band), a bluegrass band Muleskinner (album), the eponymous debut album by the bluegrass band Muleskinner "Mule Skinner Blues", a song by Jimmie Rodgers