Papadakis () is a Greek surname. The female version is Papadaki ().
Notable people with surname include: Andreas Papadakis (1938–2008), Cypriot-born British academic and architectural publisher Papadakis Publisher, British publisher Antonios Papadakis (1810–1878), Greek businessman and benefactor to the University of Athens Antonis Papadakis (1893–1980), Greek musician Christína Papadáki (born 1973), Greek tennis player Constantine Papadakis (1946–2009), Greek-American businessman and president of Drexel University Dimitris Papadakis (born 1966), Cypriot politician and MEP Eleni Papadaki (1903–1944), Greek actress Gabriella Papadakis (born 1995), French ice dancer Konstantinos Papadakis (pianist) (born 1972), Greek pianist Konstantinos Papadakis (politician) (born 1975), Greek politician and MEP Konstantinos Papadakis (basketball) (born 1998), Greek basketball player Kostas Papadakis (violinist) (1920–2003), Greek folk violinist Nick Papadakis (born 1943), Canadian soccer player Petros Papadakis (born 1977), American football player and radio host Iosif Papadakis (born 1960), Greek Astrophysiscist at the University of Crete
Fictional Hannie Papadakis, a character from The Baby-sitters Club