Margaritis () is a Greek surname. The female version is Margariti (Greek: Μαργαρίτη). It may refer to:
Alexandros Margaritis (born 1984), Greek-German racing driver Dimitrios Margaritis, fighter in the Greek War of Independence Filippos Margaritis, merchant, member of the Filiki Eteria Filippos Margaritis (1839–1892), Greek photographer Giorgos Margaritis (born 1991), Greek footballer Yannis Margaritis, Greek theatre director
See also Margariti, a municipality in Greece Margariti, a settlement in Greece