Kelch-like protein 20 is a protein that in humans is encoded by the KLHL20 gene.

The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44–56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein–protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities.

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