A briefcase is a case for carrying documents. The term may also refer to:

In computing: Briefcase (Microsoft Windows) Yahoo! Briefcase, formerly a free file hosting service by Yahoo! Briefcase, a virtual file system used in DOS Navigator orthodox file manager Briefcase, a term used in horse training to describe the act of getting the horse used to a bridle Nuclear briefcase, portable equipment to facilitate a leader of a nuclear weapons state ordering use of nuclear weapons, sometimes carried within a specialized briefcase The Briefcase, a CBS reality television series The Briefcase (Australia), a Channel Nine reality television series