Mosbacher is a surname. Notable people with the surname include:
Dee Mosbacher (born 1949), American filmmaker and lesbian feminist, daughter of Robert Emil Mosbacher (1922–1997), American yachtsman Eric Mosbacher (1903–1998), English journalist Georgette Mosbacher (born 1947), American businesswoman and Republican fundraiser; former wife of Robert Peter Mosbacher (1912–1977), German actor Robert Mosbacher (1927–2010), American businessman, United States Secretary of Commerce, yachtsman Robert Mosbacher Jr. (born 1951), American businessman and Republican politician; former head of the Overseas Private Investment Corporation; son of Robert