Antonio Guzmán may refer to:
Antonio Leocadio Guzmán (1801–1884), Venezuelan politician, journalist, and military leader Antonio Guzmán Blanco (1829–1899), president of Venezuela Antonio Guzmán Fernández (1911–1982), president of the Dominican Republic Antonio Guzmán (footballer) (born 1953), Spanish footballer Antonio Jose Guzman (born 1971), Dutch Panamanian artist