Transmembrane and ubiquitin-like domain-containing protein 2 is a protein that in humans is encoded by the TMUB2 gene.
Gene TMUB2 maps on the human chromosome 17, at locus 17q21.31. TMUB2 sits between two neighboring genes, ASB16-AS1 to the left and ATXN7L3 to the right.UCSC Genome Browser: BLAT Search TMUB2 is 4.99Kb long. The TMUB2 gene can be transcribed into three possible mRNA variants.NCBI Gene: TMUB2
Expression TMUB2 is likely ubiquitously expressed throughout the human body.EST Profile Viewer: Human It has a high expression level that is 2.9 times higher than other human genes.Aceview: TMUB2NCBI GEO Profiles
Protein The TMUB2 protein has a function that is not currently known. It consists of a 321 amino acid long chain in humans. The human protein has a molecular weight of 33.8kdal, an isoelectric point of 4.73899, and three transmembrane regions.SDSC Biology Workbench 2.0 These will likely vary in orthologs.
Homology Paralogs TMUB1 is the only paralog of TMUB2.GeneCards: TMUB2NCBI Gene: TMUB1 These proteins share a 38% identity and 51% similarity.
Orthologs The table below presents a selection of some of the TMUB2 orthologs to display protein diversity among species.NCBI BLAST: Basic Local Alignment Search Tool Species Common name Accession number Sequence length (aa) Sequence identity Sequence similarity Pan troglodytes Chimpanzee XP_003953053.1 301 100% 100% Felis Catus Cat XP_003997025.1 322 95% 95% Mus Musculus Mouse AAH29841.2 319 85% 88% Alligator Mississippiensus Alligator XP_006271613.1 306 61% 71% Haliaeetus leucocephalus Bald Eagle XP_010559728 301 59% 70% Danio rerio Zebrafish NP_001005573.1 291 47% 60% Acromyrmex echinatior Ant XP_011049429.1 354 23% 42% Nannochloropsis Gaditana* Algae EWM26843.1 476 41% 54% Coccidioides immitis RS* Pathogenic Fungus XP_001242306.1 418 38% 50%*Limited Query Coverage
Protein Interactions In humans, Ubiquitin C (UBC) is a protein with a known interaction with TMUB2. Other proposed interactions include BCL2L13 (BCL2-like 13), SGTA (Small glutamine-rich tetratricopeptide repeat-containing protein), and UBQLN1 (Ubiquilin-1).STRING: Functional Protein Association NetworksBioGRID Database
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