SPPL2B

Signal peptide peptidase-like 2B, also known as SPPL2B, is a human gene.

Gene

Multiple transcript variants encoding different isoforms have been found for this gene.

Subcellular distribution

This enzyme localizes to endosomes, lysosomes, and the plasma membrane.

Structure

This gene is a member of the signal peptide peptidase-like protease (SPPL) family with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs).

Function

This protein plays a role in innate and adaptive immunity by cleaving TNFα in activated dendritic cells. SPPL2b also modulates APP cleavage and Aβ production.

References

Further reading