Methionine aminopeptidase 1 is an enzyme that in humans is encoded by the METAP1 gene. This enzyme is a methionyl aminopeptidase which cleaves the N-terminal methionine from precursor proteins, with particular affinity for when the second amino acid is small and non-charged. Also important for the normal functioning of the cell cycle. This enzyme uses metal cations as a cofactor (making it a metalloprotein), but which one is used in the body remains debated.
See also Methionine aminopeptidase 2
References
Further reading
External links PDBe-KB provides an overview of all the structure information available in the PDB for Human Methionine aminopeptidase 1