Solute carrier family 67 member A1 is a protein that in humans is encoded by the SLC67A1 gene. It was originally denoted SLC22A18, but further research suggested that it was not closely related to other SLC22 members.

Function

This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described.

See also Solute carrier family

References

Further reading