U.S. Highway 25 (US 25) is a United States Numbered Highway that travels from Brunswick, Georgia, to the Kentucky–Ohio state line, where Covington, Kentucky, meets Cincinnati, Ohio, at the Ohio River. In the U.S. state of Georgia, US 25 is as a highway that travels south to north in the eastern part of the state, near the Atlantic Ocean, serving Statesboro and the Brunswick and Augusta metropolitan areas on its path from Brunswick to South Carolina at the Savannah River. Its routing travels through portions of Glynn, Wayne, Long, Tattnall, Evans, Bulloch, Jenkins, Burke, and Richmond counties.

The segment of US 25 from Interstate 16 (I-16) south-southwest of Statesboro north to Millen is the western segment of the Savannah River Parkway, a four-lane divided highway that roughly parallels the Savannah River. The segment from Millen north to I-520 in Augusta is the combined segment of the parkway. This highway is being considered for inclusion as part of I-3, which is ultimately planned to stretch from Savannah to Knoxville, Tennessee.

Route description Glynn County US 25 begins at an intersection with US 17/State Route 25 (SR 25; Glynn Avenue) in the southern part of Brunswick in Glynn County. This intersection also marks the southern end of SR 25 Connector (SR 25 Conn.). This intersection is west of the Marshes of Glynn Overlook Park and is north of Howard Coffin Park. US 25 and SR 25 Conn. travel concurrently on Gloucester Street to the west. At the intersection with US 341/SR 27 (Oglethorpe Street), SR 25 Conn. ends, and US 25 begins a nearly concurrency with US 341/SR 27. The three highways travel to the north. Just after F Street, they curve to the northeast and skirt along the western edge of Gateway Park. On the northern edge of the park, they intersect Newcastle Street and turn left, back to the north. Between L and M streets, the concurrency passes just to the southwest of Orange Park, and, between Q and R streets, they pass to the southwest of Palmetto Park. Between the intersection with Oak Street/1st Street, US 25/US 341/SR 27 pass Greenwood Cemetery. Between 2nd and 5th streets, they pass Selden Park. Between 4th and 7th streets, they pass Palmetto Cemetery. At 7th Street, they enter Dock Junction. Just before 9th Street, the concurrency passes Acco Park. Farther north, they intersect SR 303 (Blythe Island Highway/Community Road). The roadway passes to the southwest of Ballard Park and cross over the Brunswick–Altamaha Canal. Immediately, US 25/US 341/SR 27 begin to curve to the northwest. Approximately later, they cross over Yellow Bluff Creek. Only about later, they have an interchange with I-95 (Purple Heart Trail). At Crispen Boulevard, the concurrency leaves the city limits of Dock Junction. They cross over Burnett Creek and travel through Pyles Marsh, before curving back to the north. Immediately after that curve, the three highways travel through Brobston. Just before entering Sterling, they pass east of Sterling Park. In town, they intersect SR 99, as well SR 32. The highways travel through Pennick and Zuta, before passing to the southeast of Berry Lake. After traveling through Everett, they enter Wayne County.

Wayne County When the concurrent routes pass Mt. Pleasant Cemetery, they curve back to the northwest, travel through Mount Pleasant and cross over Alex Creek. After traveling through Grangerville, Pendarvis, and Gardi, they make a slight westward jog in Odessa; then, they cross over Ponholloway Creek, before entering Jesup. In town, US 25 splits off from US 341/SR 27 (East Cherry Street) to the north and intersects US 301/SR 23, with which US 25 begins traveling concurrently. The three highways travel north in the northeast part of the city. They curve to the northwest, before curving back north and meeting US 84/SR 38, which join the concurrency. Immediately afterward, the five highways travel to the north and leave the city limits. The concurrency travels through rural parts of the county, before traveling through Doctortown, curving to the northeast, and crossing over the Altamaha River into Long County on the Dr. J. Alvin Leaphart Sr. Memorial Bridge.

Long County US 25/US 84/US 301/SR 23/SR 38 continues north and travel through rural areas of the county, crossing over Forrest Pond, Back Swamp (in two places), Corker Branch, Fountain Branch, Brickyard Branch, and Jones Creek on its way to Ludowici. In town, the concurrency intersects SR 57 south, which travels to the southeast. At this intersection, US 25/US 301/SR 23, as well as SR 57 north, travel to the northwest, while US 84/SR 38 continue to the northeast. After a slight jog to the east, the roadway crosses through Wefanie. Just before leaving the county, they intersect former SR 261, today known as Marcus Nobles Road. Right after that, they curve to the north and cross over Beards Creek into Tattnall County.

Tattnall County US 25/US 301/SR 23/SR 57 travel to the east of Kicklighters Pond. After an intersection with SR 196, the roadway curves north and enters Glennville. At an intersection with SR 144 (Barnard Street), SR 23/SR 57 depart the concurrency to the northwest. At this intersection, US 25/US 301 continue to the north, concurrent with SR 73, which begins here. Just after leaving the city limits, the highways pass the Georgia Veterans Memorial Cemetery – Glennville, Stricklands Pond, and Strickland Pond Dam. Alongside Smith State Prison, the concurrency begins to curve to the north. They curve back to the northeast and cross over Beards Creek just before intersecting what used to be SR 250. After passing to the east of Durrence Pond, just west of Midway, US 25/US 301/SR 73 cross into Evans County.

Evans County The concurrency passes Union Cemetery and Evans Heights Golf Club. Approximately later, it crosses over Bull Creek. After a westward jog past Richards Pond, the highways curve to a due north routing and enter Claxton. In downtown, they intersect US 280/SR 30 (Main Street). Just before leaving town, the highways curve to the northeast. Just northeast of the city limits, US 25/US 301/SR 73 pass the Claxton Sewage Treatment Pond and Sewage Treatment Pond Dam. About later, they cross over the Canoochee River on the Claxton Bridge. They provide access to Claxton–Evans County Airport and then curve to the north. After curving back to the northeast, the highways curve north and intersect SR 169. About later, they cross into Bulloch County.

Bulloch County Almost immediately, the three highways curve to the north-northwest, passing Ephesus Cemetery, and curve back to the north-northeast and pass by Nevils Pond and Nevils Pond Dam. They again curve to the north-northwest and have an interchange with I-16 (Jim Gillis Historic Savannah Parkway). US 25/US 301/SR 73 curve to a nearly due north routing briefly before curving to the northeast and intersect SR 46, southeast of Register, just before crossing over Lotts Creek. The highways pass Riggs Lake and Riggs Lake Dam. Later on, they travel through Jimps, just before passing a campus of Ogeechee Technical College. They intersect the southern terminus of US 25 Bypass (US 25 Byp.)/SR 67 Byp. and US 301 Byp./SR 73 Byp. (Veterans Memorial Parkway) and enter Statesboro. They pass just to the west of Georgia Southern University and skirt along the eastern edge of W. Jones Lane Memorial Park. They curve to the north-northeast and cross over Little Lotts Creek before intersecting SR 67 (Fair Road). In downtown, they curve to the north-northwest and intersect US 80/SR 26 (Northside Drive East). At this intersection, US 301/SR 73 continue to the north-northwest, while US 25/SR 67 travel to the west-southwest, concurrent with US 80/SR 26. The four highway curve to the north-northwest before assuming a more northwesterly routing. After leaving the city limits, they intersect the northern terminus of US 25 Byp./SR 67 Byp. They provide access to William James Middle School. In Hopeulikit, the four highways curve to the north-northwest; then, US 80/SR 26 split off to the southwest. About later, US 25/SR 67 enter Jenkins County.

Jenkins County After continuing north, US 25/SR 67 pass Paynes Chapel Cemetery and Clifton Cemetery, before they curve northeast. They intersect SR 121, which joins the concurrency. Approximately later, immediately after traveling through Emmalane, they intersect SR 23, which also joins the concurrency. At Union Camp Logging Road, the four highways curve to the northeast and cross over the Ogeechee River. Just after entering Millen, they curve north and intersect SR 17 Byp. (South Gray Street), which joins the concurrency. At an intersection with SR 17 (Winthrope Avenue), SR 17 Byp. ends, and SR 23/SR 67 depart the concurrency to the east. Less than before leaving town, US 25/SR 121 curve to the northwest. On the northern edge of the city limits, they intersect the SR 21. The two highways pass the Magnolia Springs Country Club and travel through the southwestern part of Magnolia Springs State Park, in the community of Lawton. On the northwestern edge of the park, they pass Millen Airport and curve back north, passing Magnolia View Lake and Perkins; they curve once again to the north and enter Burke County.

Burke County The concurrency travels west of Munnerlyn, passing Jenkins Lake, makes a slight westward jog, and curves due north before curving back to the northwest in Idlewood and passing Burke County Airport. They intersect US 25 Byp./SR 121 Byp. (Burke Veterans Parkway). The mainline highways turn to the right and curve back to the north and have an interchange with the bypass route. Just before entering Waynesboro the roadway passes west of the Burke County campus of Augusta Technical College. In town, they curve to the north and intersect SR 24, which joins the concurrency. The three highways travel to the northwest and pass Burke Medical Center and the Burke County Museum. They intersect SR 56/SR 80 (6th Street). At this intersection, SR 24 departs the concurrency to the southwest. Just past 9th Street, they pass Burkeland Garden. About past the West 13th Street/Peachtree Street intersection, the concurrency begins to curve to the north to an intersection with US 25 Byp./SR 121 Byp. The mainline highways turn left and begin curving to the northwest and leave town; then, they curve north. They cross over Walnut Branch and Brier Creek, before traveling to the west of Stockton Pond. Approximately later, the highways cross over McBean Creek into Richmond County and the city limits of Augusta.

Richmond County