Calpurnia may refer to:
Ancient Rome Calpurnia gens, an ancient Roman family Calpurnia (wife of Caesar), last wife of Roman dictator Julius Caesar Calpurnia (wife of Pliny the Younger), third and last wife of Pliny the Younger and granddaughter of Calpurnius Fabatus Lex Acilia Calpurnia (67 BC), a severe law against political corruption Lex Calpurnia (149 BC), a law that established a permanent extortion court
Science Calpurnia (plant), a genus in the family Fabaceae Calpurnia, the central crater in a series of "snowman craters" on the asteroid 4 Vesta 2542 Calpurnia, an asteroid
Arts, entertainment, and media Calpurnia (band), a Canadian band Calpurnia (play), a 2018 play by Audrey Dwyer Calpurnia, African-American cook and maid for the Finch family in the novel To Kill a Mockingbird Shira Calpurnia, protagonist of three Warhammer 40,000 novels, see List of Warhammer 40,000 novels#Enforcer: Shira Calpurnia Calpurnia Virginia Tate, protagonist of the novel The Evolution of Calpurnia Tate
People with the given name Calpernia Addams, American transgender author and activist