Santa Cruz District may refer to:
Peru: Santa Cruz District, Alto Amazonas, in Alto Amazonas province, Loreto region Santa Cruz District, Cutervo, in Cutervo province, Cajamarca region Santa Cruz District, Huaylas, in Huaylas province, Ancash region Santa Cruz District, Palpa, in Palpa province, Ica region Santa Cruz District, Santa Cruz, in Santa Cruz province, Cajamarca region Santa Cruz de Andamarca District, in Huaral province, Lima region Santa Cruz de Chuca District, in Santiago de Chuco province, La Libertad region Santa Cruz de Cocachacra District, in Huarochirí province, Lima region Santa Cruz de Flores District, in Cañete province, Lima region Santa Cruz de Toledo District, in Contumazá province, Cajamarca region Costa Rica: Santa Cruz District, León Cortés Castro, in León Cortés canton, San José province Santa Cruz District, Santa Cruz, Guanacaste, in Santa Cruz canton, Guanacaste province Santa Cruz District, Turrialba, in Turrialba canton, Cartago province
See also Santa Cruz (disambiguation)