Protein SMG7 is a protein that in humans is encoded by the SMG7 gene.
Function
It is primarily known for its role in non-sense-mediated mRNA decay (NMD). Unlike other NMD components, SMG7 proteins have undergone lineage-specific expansions during evolutions, demonstrating their capacity to evolve and acquire new functions.
Clinical significance
Elevated of SMG7-AS1 (SMG7 antisense RNA 1, a long non-coding RNA gene associated with the SMG7 locus) are associated with a poorer clinical outcome in patients with skin cutaneous melanoma (SKCM). This suggests that SMG7-AS1 is a potential biomarker with for SKCM and could be used to predict to occurrence for tumor metastasis.
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Further reading