Serine/threonine-protein kinase 26 is a protein that in humans is encoded by the STK26 gene (previously MST4). It has also been called as mammalian STE20-like protein kinase 4 (MST-4).
Function
The product of this gene is a member of the GCK group III family of kinases, which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy-terminal regulatory domain that mediates homodimerization. The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130. It is also cleaved by caspase-3 in vitro, and may function in the apoptotic pathway. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Interactions
RP6-213H19.1 has been shown to interact with: CTTNBP2NL, CTTNBP2, STRIP1, MOBKL3, PDCD10, STRN3, and STRN.
References
Further reading