The year 1519 in science and technology included many events, some of which are listed here.
Exploration September 20 – Ferdinand Magellan's fleet sets sail from Sanlúcar de Barrameda to find a westabout route to Asia. "Miller Atlas" produced in Portugal.
Medicine A pandemic spreads from the Greater Antilles into Central America, and perhaps as far as Peru, killing much of the indigenous populations in these areas. Publication in Paris of Thomas Linacre's translation into Latin of Galen's Methodus medendi.
Births June 6 – Andrea Cesalpino, Italian philosopher, physician, and botanist (died 1603)
Deaths May 2 – Leonardo da Vinci, Italian polymath (born 1452)
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