Non-noradrenergic, non-cholinergic transmitter

A non-noradrenergic, non-cholinergic transmitter (NANC) is a neurotransmitter of the enteric nervous system (ENS) that is neither acetylcholine, norepinephrine, nor epinephrine.

Comparison table This table compares different NANCs in the PNS:

NeurotransmitterTypeLocation Unless else specified in table, then ref is: Page 132Function ATP non-peptide postganglionic sympathetic neurons (e.g. in blood vessels & vas deferens) Fast depolarization/contraction (vasoconstriction) GABA non-peptideENSsperistalsis 5-HT non-peptide ENSsperistalsisdopamine non-peptidesome SNSs (e.g. kidney)vasodilationNO non-peptidegastric nerves & Pelvic Nerveerection gastric emptyingNPYpeptidepostganglionic sympathetic neurons (e.g. blood vessels) enhance vasoconstrictor action of noradrenaline noradrenaline release inhibitorVIPpeptideparasympathetic nerves to salivary glands NANC innervation to smooth muscle of airways parasympathetic ganglia in sphincters, gallbladder and small intestinevasodilation acetylcholine cotransmitter bronchodilation relaxation of intestinal smooth muscle and sphinctersGnRHpeptidesympathetic gangliaslow depolarization acetylcholine cotransmittersubstance Ppeptidesympathetic ganglia ENSsslow depolarization acetylcholine cotransmitterCGRPpeptidenon-myelinated sensory neuronsvasodilation increase vascular permeability neurogenic inflammation

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