This is a table of drugs that are secreted in the kidney.
Acid medication are, because of pH partition, secreted to a higher extent when urine is basic. In the same way, basic medications are secreted to a higher extent when urine is acidic.
Medication Location Acid or baseUnless else specified in table boxes, then ref is Page 112 anion or cationUnless else specified in table boxes, then ref is Page 802 Percentage excretedUnless else specified in table boxes, then ref is Page 113 para-aminohippurate proximal tubule Page 112 Acid anion furosemide proximal tubule Acid anion 100-75 glucuronic acid-conjugates proximal tubule Acid glycine conjugates proximal tubule Acid indometacin proximal tubule Acid anion methotrexate proximal tubule Acid 100-75 penicillin proximal tubule Acid anion 75-50 (benzylpenicillin) probenecid proximal tubule Acid anion sulphate conjugates proximal tubule Acid thiazide diuretics proximal tubule Acid uric acid proximal tubule Acid amiloride proximal tubule Base cation dopamine proximal tubule Base histamine proximal tubule Base mepacrine proximal tubule Base morphine proximal tubule Base cation pethidine proximal tubule Base quaternary ammonium compounds proximal tubule Base quinine proximal tubule Base cation 5-hydroxytryptamine (serotonin) proximal tubule Base triamterene proximal tubule Base gentamicin 100-75 atenolol 100-75 digoxin 100-75 cimetidine cation 75-50 tetracycline 75-50 (oxytetracycline) neostigmine 75-50 propantheline ~50 tubocurarine ~50 acetazolamide proximal tubule Page 802 anion chlorothiazide proximal tubule anion saccharin proximal tubule anion salicylate proximal tubule anion atropine proximal tubule cation NMN proximal tubule cation paraquat proximal tubule cation procainamideproximal tubule cation tetraethylammonium proximal tubule cation chlorpromazine proximal tubule cation
References