Michael or Mike Jefferson may refer to:
Michael Jefferson, a contestant from Survivor: One World Michael Jefferson (American football) (born 1999), football wide receiver Mike Jefferson (American football) (born 1982), football wide receiver Mike Danton (né Jefferson, born 1980), former ice hockey player Trihex (Michael Ramon Jefferson), American esports player and streamer Michael Jefferson Michael Jefferson, American Esports Instructor The fake name of a character in the South Park episode "The Jeffersons".