Slayton may refer to:
People with the given name Slayton A. Evans, Jr. (1943–2001), American chemist
People with the surname Chris Slayton (born 1995), American football player Darius Slayton (born 1997), American football player Deke Slayton (1924–1993), one of the original 7 Mercury astronauts Bobby Slayton (born 1955), American comedian John W. Slayton (1861–1935), American socialist lecturer and politician Paul Wall (born Paul Slayton in 1981), American rapper Helen Slayton-Hughes (1930-2022), American actress
Places United States Slayton, Minnesota, a city Slaytonville, Arkansas, an unincorporated community