WD repeat-containing protein WRAP73 is a protein that in humans is encoded by the WRAP73 gene (previously WDR8). The gene symbol is short for "WD repeat containing, antisense to TP73", indicating the genes close position and opposite direction compared to the gene TP73.
Function
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This family member is 89% identical to the mouse Wdr8 protein at the amino acid level. The function of this protein is not known, and the mouse studies suggest that the Wdr8 protein may play a role in the process of ossification (osteogenesis).
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Further reading