Buffington is a surname. Notable people with the surname include:
Adelbert Rinaldo Buffington (1837–1922), American soldier Brett Buffington (born 1961) American former professional tennis player Byron Buffington (1852–1929), American politician Cam Buffington (born 2005), American football player Charlie Buffinton (born Buffington, 1861–1907), American baseball player George Buffington (1825–1893), American politician Joseph Buffington (1855–1947), American judge Joseph Buffington (congressman) (1803–1872), American member of Congress Nancy Buffington (1939–2021), American politician Thomas Buffington (1855–1938), American Indian Chief