Krestenitis (Greek: Κρεστενίτης) is a Greek surname. Notable people with the surname include:
Georgios Krestenitis, Greek politician Ioannis Krestenitis (elder), revolutionary leader of the Greek War of Independence Ioannis Krestenitis (younger) (died 1915), Greek politician Lykourgos Krestenitis (1793–1873), politician and a president of the Parliament of Greece Stamatis Krestenitis, revolutionary leader of the Greek War of Independence