Madame Hydra is the name of several supervillains appearing in American comic books published by Marvel Comics. It is a name given to a top female operative of Hydra.
Fictional character biography Ophelia Sarkissian
Valentina Allegra de Fontaine
Elisa Sinclair
Elisa Sinclair originates from an alternative timeline created by Kobik where Steve Rogers (Captain America) was captured by Hydra as a child and made into a sleeper agent for Hydra. In the present, Sinclair intercepts Taskmaster and Black Ant, who intended to give evidence of Captain America's brainwashing to Maria Hill.Captain America: Steve Rogers #12 (April 2017) Sinclair recruits Taskmaster and Black Ant as her personal guards.Captain America: Steve Rogers #14 (May 2017)
In the storyline Secret Empire, Sinclair reunites with Captain America after he overthrows the Red Skull for leadership of Hydra.Captain America: Steve Rogers #16 (June 2017) Following Hydra's takeover of the United States, Sinclair uses her magic to counter Doctor Strange's attempts to destroy the Darkforce dome surrounding Manhattan. While having tea with Captain America, Sinclair is informed of Captain America's suspicion about Baron Zemo and Doctor Faustus' disloyalty. Sinclair brushes off the suspicion and tells Captain America that Hydra plans to assemble the Cosmic Cube to restore Earth to their vision.Secret Empire #1 (July 2017) During Hydra's attack on the Underground's base, Sinclair sacrifices herself to save Captain America.Secret Empire #6 (September 2017)
Other versions Heroes Reborn In the Heroes Reborn reality, Madame Hydra is a terrorist leader. She answers to Hydra's leader the Mandarin, who is actually a robot built by Doctor Doom.Iron Man (vol. 2) #1 (November 1996) She is killed in battle against Iron Man.Iron Man (vol. 2) #10 (August 1997)
In other media
Television The Viper incarnation of Madame Hydra appears in X-Men: Evolution, voiced by Lisa Ann Beley. The Viper incarnation of Madame Hydra appears in The Avengers: Earth's Mightiest Heroes, voiced by Vanessa Marshall.
Film Valentina Allegra de Fontaine and Viper appear in Nick Fury: Agent of S.H.I.E.L.D., portrayed by Lisa Rinna and Sandra Hess respectively.
Marvel Cinematic Universe
Variations of individuals who have used the Madame Hydra alias in the comics appear in media set in the Marvel Cinematic Universe (MCU): A variation of Ophelia / Madame Hydra appears in the fourth season of the television series Agents of S.H.I.E.L.D. as an alias for the AI Aida, portrayed by Mallory Jansen. Aida only has the title of Madame Hydra in the Framework, while she chose the name Ophelia due to disliking her acronym name. Valentina Allegra de Fontaine appears in the Disney+ miniseries The Falcon and the Winter Soldier and the films Black Widow, Black Panther: Wakanda Forever, and Thunderbolts* portrayed by Julia Louis-Dreyfus. This version is unconnected to Hydra.
Video games Madame Hydra appears as a boss in Captain America: Super Soldier, voiced by Audrey Wasilewski. Viper appears as the first boss in Marvel: Avengers Alliance. Viper appears as a boss in Marvel: Avengers Alliance Tactics. Madame Hydra appears in Marvel Heroes, voiced by Tasia Valenza. Viper appears in Lego Marvel Super Heroes, voiced by Kari Wahlgren. Viper appears in Lego Marvel's Avengers. Madame Hydra appears as a boss in Marvel Avengers Academy. The Viper incarnation of Madame Hydra appears in Marvel Powers United VR, voiced again by Vanessa Marshall.
Miscellaneous The Viper incarnation of Madame Hydra appears in the Spider-Woman: Agent of S.W.O.R.D. motion comic, voiced by Nicolette Reed. Madame Hydra appears in Marvel Universe Live!.
Merchandise An action figure of the Viper incarnation of Madame Hydra was released in Hasbro's "Marvel Legends" line as part of the "Marvel's Madames" sub-line.
References
External links Madame Hydra (Heroes Reborn) at Marvel Wiki Madame Hydra (Elisa Sinclair) at Marvel Wiki Madame Hydra VI at Marvel Appendix