Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.
Function
The protein encoded by this gene is a transcriptional coactivator that can interact with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, histone acetyltransferases, and methyltransferases.
Interactions NCOA6 has been shown to interact with:
ASCL2 and Activating transcription factor 2, Androgen receptor, CREB-binding protein, DNA-PKcs, E2F1, EP300, Estrogen receptor alpha, Estrogen receptor beta, HBXIP, HIST2H3C, HSF1, Ku70, Ku80, Liver X receptor beta, MLL3, RBBP5, Retinoblastoma protein, Retinoic acid receptor alpha, Retinoid X receptor alpha, Src, TGS1, TUBA4A, TUBB, Thyroid hormone receptor alpha, and Thyroid hormone receptor beta.
See also Transcription coregulator
References
Further reading
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