Aldo-keto reductase family 1 member C1 is an enzyme that in humans is encoded by the AKR1C1 gene. This multi-functional enzyme is involved in degrading progesterone and androgens, as well as producing the active neurosteroid 3alpha,5alpha-THDOC. More generally, it can function as a 20α-hydroxysteroid dehydrogenase, and a 3α-hydroxysteroid dehydrogenase, among other functions.
Superfamily of enzymes
This gene encodes a member of the aldo-keto reductase family which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity.
AKR1C family The AKR1C1 gene shares high sequence identity with three other gene members that are clustered at chromosome 10p15-p14.
References
See also
3α-Hydroxysteroid dehydrogenase
External links
Further reading