What's Up or variants may refer to: Film and television What'z Up?, 1994 American teens TV show What's Up (TV series), 2011–12 South Korean musical drama What's Up! Que Pasa, American children's educational TV show WatsUp TV, pan-African series of TV shows Whassup?, advertising campaign for Budweiser-brand beer What's Up: Balloon to the Rescue, mockbuster by Vídeo Brinquedo
Music What's Up? (musical), Lerner and Loewe musical
Albums What's Up (Bill Hardman album), 1989 What's Up? (Michel Camilo album), 2013 What's Up?, an album by Klaus "Major" Heuser Band, 2016
Songs "What's Up?" (4 Non Blondes song), 1992 "What's Up" (Myname song), 2012 "Wassup", by Joey Valence & Brae featuring JPEGMafia, 2025 "What Up?", by Pimp C from his 2010 album The Naked Soul of Sweet Jones
Groups Wassup (group), South Korean girl group What's Up!, Swedish boy band
Other uses What's Up (weekly), newspaper in El Paso, Texas
See also Wazzup Wazzup, Philippine comedic-news TV series WhatsApp, instant messaging application for smartphones