Integrin beta 5

Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.

Interactions Integrin, beta 5 has been shown to interact with PTK2, Annexin A5 and PAK4.

Functions ITGB5 encodes a subunit of integrin that can interact with the integrin alpha v to form the integrin alpha v beta 5 integrin heterodimer. Integrin alpha V beta 5 is a receptor for the extracellular matrix protein Vitronectin and can form both focal adhesions and reticular adhesions. DOI: 10.1083/jcb.201811160

Clinical significance

Research Elevated levels of ITGB5 have been found in patients with autosomal dominant osteopetrosis type II, a rare disease of bones.

References

Integrin beta 5

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