Calpain-1 catalytic subunit

Calpain-1 catalytic subunit (CAPN 1) is a protein that in humans is encoded by the CAPN1 gene.

Function

The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1.

Interactions

CAPN1 has been shown to interact with PSEN2.

References

Calpain-1 catalytic subunit

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