USS Serapis may refer to the following ships operated by the United States Navy:
Serapis, was a British frigate known as captured by John Paul Jones and the crew of Bonhomme Richard in 1779. She was later sold to France. Serapis, was a planned Algoma-class sloop, authorized in 1864 but never laid down , was a single-screw tanker built in 1921 and originally named District of Columbia.