UMP kinase () is an enzyme that catalyzes the chemical reaction
The enzyme characterised from Escherichia coli and Pyrococcus furiosus converts the nucleotide, uridine monophosphate, to uridine diphosphate by transferring a phosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine diphosphate (ADP).
Nomenclature The enzyme is a transferase, specifically one transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:UMP phosphotransferase. Other names in common use include uridylate kinase, UMPK, uridine monophosphate kinase, PyrH, UMP-kinase, and SmbA.
Structural studies As of March 2010, 19 structures have been solved for this class of enzymes, and are deposited in the Protein Data Bank. All have a 3-layer (aba) sandwich) architecture (CATH code 3.40.1160.10). These include accession codes , , , and .
Search for all UMP Kinases in the PDB using the enzyme Browser at PDBe. (input the EC number)
References