Thiamine diphosphokinase () is an enzyme that catalyzes the chemical reaction
The enzyme characterised from rat liver and yeast converts thiamine to thiamine pyrophosphate by transferring a pyrophosphate group from the cofactor, adenosine triphosphate (ATP), which is converted to adenosine monophosphate (AMP).
This enzyme is a transferase, specifically one transferring two phosphorus-containing groups (diphosphotransferases). The systematic name of this enzyme class is ATP:thiamine diphosphotransferase. Other names in common use include thiamin kinase, thiamine pyrophosphokinase, ATP:thiamin pyrophosphotransferase, thiamin pyrophosphokinase, thiamin pyrophosphotransferase, thiaminokinase, thiamin:ATP pyrophosphotransferase, and TPTase.
Structural studies As of late 2007, six structures have been solved for this class of enzymes, with PDB accession codes , , , , , and .
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