Serine-phosphoethanolamine synthase () is an enzyme that catalyzes the chemical reaction

The enzyme isolated from chicken combines cytidine diphosphate ethanolamine (CDP-ethanolamine) and L-serine to give cytidine monophosphate and L-serine phosphoethanolamine.

This enzyme is a transferases, specifically one transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-ethanolamine:L-serine ethanolamine phosphotransferase. Other names in common use include serine ethanolamine phosphate synthetase, serine ethanolamine phosphodiester synthase, serine ethanolaminephosphotransferase, serine-phosphinico-ethanolamine synthase, and serinephosphoethanolamine synthase.

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