Pantetheine-phosphate adenylyltransferase () is an enzyme that catalyzes the penultimate step in the biosynthesis of coenzyme A. It combines adenosine triphosphate and phosphopantetheine to give 3'-dephospho-Coenzyme A, with inorganic pyrophosphate (PPi) as a byproduct:
The enzyme has been characterised from Brevibacterium ammoniagenes and Escherichia coli. The final step to coenzyme A is catalysed by dephospho-CoA kinase.
Nomenclature The enzyme is a transferase, specifically one transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:pantetheine-4'-phosphate adenylyltransferase. Other names in common use include dephospho-CoA pyrophosphorylase, pantetheine phosphate adenylyltransferase, dephospho-coenzyme A pyrophosphorylase, and 3'-dephospho-CoA pyrophosphorylase.
Structural studies As of late 2007, 8 structures have been solved for this class of enzymes, with Protein Data Bank accession codes , , , , , , , and .
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