Glucose-1-phosphate guanylyltransferase () is an enzyme that catalyzes the chemical reaction
The enzyme characterised from mast cell tumors combines guanosine triphosphate and glucose 1-phosphate to give GDP-glucose, with pyrophosphate (PPi) as a byproduct. In Streptomyces venezuelae this reaction is part of the biosynthetic pathway to trehalose 6-phosphate.
This enzyme is a transferase, specifically one transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:alpha-D-glucose-1-phosphate guanylyltransferase. Other names in common use include GDP glucose pyrophosphorylase, and guanosine diphosphoglucose pyrophosphorylase.
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