In biochemistry, a dual-specificity kinase () is a kinase that can act as both tyrosine kinase and serine/threonine kinase.
MEKs, involved in MAP pathways, are principal examples of dual-specificity kinases. Other common examples include: ADK1 (Arabidopsis dual specificity kinase 1) CLK1, CLK2, CLK3, CLK4 DSTYK DYRK1A, DYRK1B, DYRK2, DYRK3, DYRK4 Mps1p TESK1, TESK2 TTK
The systematic name of this enzyme class is ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating).
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