Cyclopeptine synthase () is an enzyme that catalyzes the chemical reaction
anthranilate + L-phenylalanine + S-adenosyl-L-methionine + 2 ATP cyclopeptine + 2 AMP + S-adenosyl-L-homocysteine + 2 diphosphate + 2 H(+)
In Penicillium cyclopium, cyclopeptine synthase is important for benzodiazepine alkaloid biosynthesis.
Enzyme Classification History Formerly, cyclopentine synthase activity was classified under two separate enzymes. anthranilate adenylyltransferase () catalyzes the partial reaction
ATP + anthranilate diphosphate + N-adenylylanthranilate
phenylalanine adenylyltransferase () catalyzes the partial reaction
ATP + L-phenylalanine diphosphate + N-adenylyl-L-phenylalanine
and were reclassified and merged into .
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