In enzymology, a galactoside 2-alpha-L-fucosyltransferase () is an enzyme that catalyzes the chemical reaction
GDP-beta-L-fucose + beta-D-galactosyl-R GDP + alpha-L-fucosyl-1,2-beta-D-galactosyl-R
Thus, the two substrates of this enzyme are GDP-beta-L-fucose and beta-D-galactosyl-R, whereas its two products are GDP and alpha-L-fucosyl-1,2-beta-D-galactosyl-R.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. This enzyme participates in 4 metabolic pathways: glycosphingolipid biosynthesis - lactoseries, glycosphingolipid biosynthesis - neo-lactoseries, glycosphingolipid biosynthesis - globoseries, and glycan structures - biosynthesis 2.
Nomenclature The systematic name of this enzyme class is: GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase Other names in common use include: blood group H alpha-2-fucosyltransferase guanosine diphosphofucose-galactoside 2-L-fucosyltransferase alpha-(1->2)-L-fucosyltransferase alpha-2-fucosyltransferase alpha-2-L-fucosyltransferase blood-group substance H-dependent fucosyltransferase guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase guanosine diphosphofucose-lactose fucosyltransferase GDP fucose-lactose fucosyltransferase guanosine diphospho-L-fucose-lactose fucosyltransferase guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase
alpha-L-fucosyltransferase, guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase H-gene-encoded beta-galactoside alpha1->2fucosyltransferase secretor-type beta-galactoside alpha1->2fucosyltransferase beta-galactoside alpha1->2fucosyltransferase GDP-L-fucose:lactose fucosyltransferase
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