The class C G-protein-coupled receptors () are a class of G-protein coupled receptors that include the metabotropic glutamate receptors () and several additional receptors.
Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length. This protein family includes metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors.
Subfamilies
Calcium-sensing receptor-related extracellular calcium-sensing receptor-related Calcium-sensing receptor () GPRC6A ()
GABAB receptors GABAB receptor (gamma-aminobutyric acid) GABAB receptor 1 () GABAB receptor 2 ()
Metabotropic glutamate receptors Metabotropic glutamate receptors (mGluR) mGluR1 () mGluR2 () mGluR3 () mGluR4 () mGluR5 () mGluR6 () mGluR7 () mGluR8 ()
RAIG Retinoic acid-inducible orphan G protein-coupled receptors (RAIG) RAIG1 () RAIG2 () RAIG3 () RAIG4 ()
Taste receptors Taste receptor Taste receptor, type 1, member 1 () Taste receptor, type 1, member 2 () Taste receptor, type 1, member 3 ()
Orphan Class C Orphan receptors GPR158 () GPR179 () GPR156 ()
Other Bride of sevenless protein Vomeronasal receptor, type 2
References