Thyroid-hormone transaminase () is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme characterised from rabbit kidney and liver are the thyroid hormone, triiodothyronine, and α-ketoglutaric acid. Its products are 3,5,3'-triiodothyropyruvic acid and L-glutamic acid.
This enzyme is a transferase, specifically a transaminase, which transfer nitrogenous groups. The systematic name of this enzyme class is L-3,5,3'-triiodothyronine:2-oxoglutarate aminotransferase. Other names in common use include 3,5-dinitrotyrosine transaminase, and thyroid hormone aminotransferase. It uses pyridoxal phosphate as a cofactor.
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